Eyes on coronavirus

Eyes on systems pharmacology.

As an emerging subdiscipline of pharmacology, one of the priary goals of systems pharmacology is to elucidate therapeutic echanisms of combined pharmacological strategies used to treat iverse complex diseases in which multiple integrated cellular athways are perturbed. Mechanistic insights into disease pathogenesis are critical for ptimal therapeutic development. With the exception of rare onoo...

Eyes on the Vulnerable.

Keep Eyes on Integrins

In mammals, there are 18 kinds of α subunit and 8 kinds of β subunit were discovered, which form 24 combinations (Table 1) [2,3]. Overall, these 24 kinds of integrins can be divided to two groups by containing α-I domain (Table 1 and Figure 1A) or not (Table 1 and Figure 1B). Integrin can regulate its ligand-binding affinity by conformational changes [1]. The adaptor proteins and signal pathway...

Eyes on chromosomes.

Multigene RNA vector based on coronavirus transcription.

Coronavirus genomes are the largest known autonomously replicating RNAs with a size of ca. 30 kb. They are of positive polarity and are translated to produce the viral proteins needed for the assembly of an active replicase-transcriptase complex. In addition to replicating the genomic RNA, a key feature of this complex is a unique transcription process that results in the synthesis of a nested ...